Abstract
The title compound {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propylamine}, C14H20N2, has a single molecule in the asymmetric unit. The molecules in the unit cell are held together in infinite one-dimensional chains along [010] through N—H...N hydrogen bonds between indole H atoms and trialkylamine N atoms.
Highlights
The title compound {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propylamine}, C14H20N2, has a single molecule in the asymmetric unit
N-Methyl-N-propyltryptamine (MPT) is a structural analog of N,N-dimethyltryptamine (DMT), which is a well known ‘psychedelic’ molecule found in a variety of naturally occurring organisms, including plants, animals, and funghi, including mushrooms
Occurring tryptamines (e.g. DMT, psilocybin, 5methoxy-N,N-dimethyltryptamine) and their synthetic derivatives have garnered considerable attention of late due to new evidence demonstrating their efficacy in treating mood and post traumatic stress disorders (PTSDs) (Aixalaet al., 2018; Cameron et al, 2019)
Summary
N-Methyl-N-propyltryptamine (MPT) is a structural analog of N,N-dimethyltryptamine (DMT), which is a well known ‘psychedelic’ molecule found in a variety of naturally occurring organisms, including plants, animals, and funghi, including mushrooms. Occurring tryptamines (e.g. DMT, psilocybin, 5methoxy-N,N-dimethyltryptamine) and their synthetic derivatives (e.g. psilacetin, MPT) have garnered considerable attention of late due to new evidence demonstrating their efficacy in treating mood (e.g. anxiety and depression) and post traumatic stress disorders (PTSDs) (Aixalaet al., 2018; Cameron et al, 2019). Psilocybin, isolated from the so-called ‘magic’ mushrooms, is perhaps the best known prodrug of the serotonin 2a agonist psilocin (Nichols, 2016). Recent studies indicate that psilocin (and its prodrugs like psilocybin and psilacetin) could provide effective treatment for mood disorders, end-of-life anxiety, addiction, and PTSD (Carhart-Harris et al, 2016; Johnson & Griffiths, 2017).
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