Abstract
The frequency and significance of antibodies to NMDAR were determined in 19 adolescents and young women, aged 15 to 45 years, with unexplained new-onset epilepsies, seen between Jan 2005 and June 2007 at the University of Bonn, Germany; Univ of Pennsylvania, Philadelphia; and John Radcliffe Hospital, Oxford, UK.
Highlights
In a control series of 61 patients with other cryptogenic epilepsies and 11 surgically treated patients with epilepsy, one, a 22-yearold man, was NMDAR antibody positive and he had recovered from a severe encephalopathy
A significant proportion of unexplained new-onset epilepsies in adolescents and young women may be caused by anti-NMDAR encephalitis
Seizures are a common symptom in patients with anti-NMDAR encephalitis, reported in 76 of 100 cases (Dalmau J et al 2008)
Summary
The value of early seizure frequency and etiology in the prediction of long-term seizure and mortality outcome in a population-based cohort of 102 children was determined in a study at University of Turku, Finland, and Epilepsy Research Group, Berlin, Germany. The frequency and significance of antibodies to NMDAR were determined in 19 adolescents and young women, aged 15 to 45 years, with unexplained new-onset epilepsies, seen between Jan 2005 and June 2007 at the University of Bonn, Germany; Univ of Pennsylvania, Philadelphia; and John Radcliffe Hospital, Oxford, UK. Five (25%) patients had anti-NMDAR antibodies, and all 5 had a history of psychiatric symptoms, pleocytosis, seizures, and relapsing-remitting course. Either spontaneously or following corticosteroid or intravenous immunoglobulin treatment.
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