Abstract
NMDA receptors (NMDARs) are essential for normal physiological processes in the central nervous system, e.g. development, induction of synaptic plasticity, learning and memory. Excessive activation of NMDARs can lead to neuronal damage in many acute (hypoxic–ischaemic injury) and chronic neurodegenerative diseases (Alzheimer, Parkinson, Huntington). This dual role of NMDARs in normal and abnormal brain functioning imposes constraints on possible therapeutic strategies involving NMDAR antagonists. Blockade of excessive NMDAR activity must therefore be achieved without interference with physiological activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
