Abstract
The effects of new nootropic dipeptide GVS-111 (N-phenylacetyl-L-prolylglycine ethyl ester) on EEG spectral characteristics were compared with those of piracetam. The EEG was recorded in the cortex and hippocampus of nonanesthetized nonrestrained rats with chronically implanted electrodes. GVS-111 and piracetam induced similar changes in EEG spectral profile in both structures increasing the α-band power and decreasing the power of the β-and δ-bands. These effects were prevented by intracerebral injection of 10−10 mol NMDA receptor antagonist (±)-3-(2-carboxypiperazine-4-il)-propyl-l-phosphonic acid. The data correlate with behavioral and neurochemical findings and suggest that NMDA receptors can be specifically involved in the mechanisms of nootropic effects of piracetam and GVS-111.
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