Abstract

NOD-like receptor protein 3 (NLRP3) inflammasomes play an important role in innate immunity. It can induce the maturation and release of cytokines interleukin (IL) -1β and IL-18 by activating caspase-1, and participate in a variety of host immunoinflammatory responses. Once the regulation of NLRP3 inflammasomes is unbalanced, excessive IL-1β and IL-18 may be produced, triggering a series of inflammatory diseases. NLRP3 inflammasome activation plays important roles in skin diseases such as acne, psoriasis, pyoderma gangrenosum, polymyositis/dermatomyositis and bullous pemphigoid. This review summarizes research progress in NLRP3 inflammasomes in skin diseases. Key words: Inflammasomes; Interleukin-1beta; Interleukin-18; Skin diseases; NLRP3

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