Abstract
Wang Z et al. recently published a paper, titled “Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment”. The finding in this paper is consistent with our previous study on NLRP3-caspase-1 pathway. Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.
Highlights
Wang Z et al recently published a paper, titled “Critical role of NOD-like receptor protein 3 (NLRP3)-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment”
“Critical role of NLRP3-caspase-1 pathway in agedependent isoflurane-induced microglial inflammatory response and cognitive impairment” by Dr Wang Z et al [1], who concluded that NLRP3 priming status in aged mouse brain may be involved in isoflurane-induced hippocampal inflammation and cognitive impairment
We have previously shown that isoflurane induces activation of NLRP3, cleavage of caspase 1, and increase of IL-1β and Tumor necrosis factor-α (TNF-α) levels in the hippocampus of aging mice and supposed that inhibiting the NLRP3 inflammasome might have therapeutic merit for ameliorating general anesthesia-induced cognitive deficits [5] as cited in Wang’s study
Summary
Wang Z et al recently published a paper, titled “Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment”. “Critical role of NLRP3-caspase-1 pathway in agedependent isoflurane-induced microglial inflammatory response and cognitive impairment” by Dr Wang Z et al [1], who concluded that NLRP3 priming status in aged mouse brain may be involved in isoflurane-induced hippocampal inflammation and cognitive impairment. The NLRP3 inflammasome-caspase-1 pathway has been implicated in several metabolic and inflammatory diseases [2, 3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
