Abstract
NK receptors: tools for a polyvalent cell family.
Highlights
In these last years, along with the description of new NK cell types playing key roles within different body compartments, it is becoming conceivable that NK cell receptors might have been shaped to fulfill a complex array of functions beyond the simple recognition of pathological cells [1, 2]
Whether the peptide could have a role in the HLA-I recognition by activating KIRs is still unclear
Several CLPD-NK cases present an expansion of activating KIRs (aKIRs)+ NK cells, which are, characterized by reduced NCR-mediated function
Summary
Along with the description of new NK cell types playing key roles within different body compartments, it is becoming conceivable that NK cell receptors might have been shaped to fulfill a complex array of functions beyond the simple recognition of pathological cells [1, 2]. Cassidy et al [5] focus on the KIR ligands, the MHC-I molecules, and analyze the role of the MHC-I peptide content in such receptor/ligand interaction suggesting that NK cells can perceive in some ways intracellular modifications in tumor or virally infected cells. Education by aKIRs shares features with the hyporesponsiveness induced by chronic stimulation of other activating receptors expressed by NK cells [7].
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