Abstract
To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student’s t test, F test, and Brown–Forsythe test were used for comparison between groups of variables. Associations were assessed with Pearson coefficient. Patients with RF had lower lymphocyte count than controls. Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3+CD16+CD56+ phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3+CD16+CD56+ phenotype; a significant decrease in the number and percentage of T CD3+ cells. The number of NK cells was strongly positively correlated with the number of CD3 cells (r = 0.6162). The number of NKT cells was strongly positively correlated with CD3 cells (r = 0.6885) and CD3CD8 cells (r = 0.5465). Periodic exacerbations in RF are associated with the development of furuncles, which are a result of many already discovered as well as just being examined mechanisms. One of them is a significant increase in the number and most likely activation of NK and NKT-like cells during the formation of the inflammatory process and furuncles.
Highlights
Furuncles and furunculosis are the most common skin infections in dermatogical practice
A significant decrease in the lymphocyte count in patients with recurrent furunculosis in comparison with healthy controls undoubtedly results from the characteristics of bacterial inflammatory process
The stimulation of Natural killer (NK) cells by dendritic cells and macrophages is necessary for the activation of their cytotoxic capacity (Hall et al 2013; Horowitz et al 2011)
Summary
Furuncles and furunculosis are the most common skin infections in dermatogical practice. Natural killer (NK) cells are a part of the lymphatic system. They are produced in the bone marrow where they enter into the circulation and migrate to the liver, spleen,. The mean percentage of NK cells accounts for about 10% They have a similar morphologic structure like that of the lymphocytes, but they have small granules in their cytoplasm. NK cells were regarded responsible only for non-specific cellular immunity involved in the antiviral and anticancer defense. Still, their particular importance reflects the fight with viral infections and cancer diseases. Researchers emphasize the role of NK cells in the antibacterial defense in various locations in the organisms such as the mucosa of digestive, respiratory, and reproductive system as well as joints or even nervous system (Ivanova et al 2014; Shi et al 2011)
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