Abstract
Summary. The aim of this study was to investigate nitrite blood levels (NO2 –) and the total nitrite and nitrate concentration (Σ NO2 – / NO3 –) in the exhaled breath condensate (EBC) and to evaluate interrelationships between NO metabolites and serum sCD50, sCD54, sHLA-I, sCD95 soluble differentiation molecules in patients with exacerbation of chronic obstructive pulmonary disease (COPD). We examined 110 patients with exacerbation of COPD stages I–III and 28 healthy non-smokers. Exacerbation of COPD stages II and III was found to be related to a significant increase in NO2 level in the blood and (Σ NO2 – / NO3 –) in EBC, increased concentrations of sCD50, sCD54, sHLA-I molecules and decreased concentration of sCD95 molecules. Statistically significant strong relationships were found between nitrous stress parameters and serum concentrations of soluble differentiation molecules in exacerbation of COPD. These data could indicate a role of soluble sCD50, sCD54, sHLA-I, sCD95 molecules and nitrous stress in the pathogenesis of COPD progression. These biomarkers could be used as predictors of poor prognosis of early-stage COPD and as diagnostic criteria of exacerbation of COPD stages II–III.
Highlights
We examined 110 patients with exacerbation of chronic obstructive pulmonary disease (COPD) stages I–III and 28 healthy non smokers
В настоящем исследовании у больных с обостре нием ХОБЛ II и III стадии установлены достоверное увеличение уровня метаболитов NO в крови и конденсате вы дыхаемого воздуха (КВВ), повышение сывороточного содержания раствори мых форм молекул адгезии (CD50, sCD54) и гисто совместимости I класса (sHLA I), а также снижение концентрации белков sСD95
Summary
Л.Б.Постникова 1, Н.И.Кубышева 2, М.В.Болдина 1, Т.В.Ли 3, И.А.Климанов 4, В.В.Новиков 5. – Государственное бюджетное учреждение здравоохранения Нижегородской области "Городская больница No 28" (Городской консультативный центр для больных ХОБЛ): 603035, Нижний Новгород, ул. – Государственное бюджетное учреждение здравоохранения Нижегородской области "Детская городская клиническая больница No 27 "Айболит": 603035, Нижний Новгород, ул. Островитянова, 1; 4 – ФГУ "НИИ пульмонологии" ФМБА России: 105077, Москва, ул. 4; 5 – НИИ молекулярной биологии и региональной экологии Нижегородского государственного университета им.
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