Abstract
The most prevalent strategies for preparing halogenated alkyl aromatics face one remarkable challenge: low regioselectivity. Therefore, the highly regioselective halogenation of alkyl arenes is still an unsolved problem. Herein, a highly regioselective halogenation of alkyl aromatics through nitromethane-assisted Brønsted acid catalysis is disclosed. Under the mild reaction conditions, a wide diversity of halogenated alkyl aromatics is obtained in high yields with excellent regioselectivity. The hydrogen bonding of protonic acid with the solvent nitromethane promotes this transformation.
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