Abstract
Hydroxyapatite (HAp) with the chemical formula of Ca10(PO4)6(OH)2is a mineral component found in bone structure, and has broad application in many fields. Several sources can be used for the extraction of HAp either synthetic or natural. However, sources such as porcine and bovine have drawbacks that decreased the demand of HAp. This study aimed to extract and determine particle size distribution and pore characteristics of hydroxyapatite nanoparticles (HAp NPs) derived from spotted sardinella (Amblygaster sirm). Further characterization of extracted HAp NPs was carried out by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS) and Brunauer–Emmett–Teller(BET). SEM analysis has shown that the extracted HApNPs has an irregularsp here-like shape with particle size distribution ranged from 95nm to 100nm.
Highlights
Bone is a combination of organic and inorganic components that provides mechanical strength and stability to the structure (Dorozhkin, 2013)
The morphological structure of raw bone (RB) showed an amorphous shape and size consisting of decomposed inorganic materials and the small size of the hydroxyapatite (HAp) particle
This phenomenon could be due to the composition of inorganic materials contained in the RB, including HAp particle that has a particle size distribution ranging from 90 to 100 μm
Summary
Bone is a combination of organic and inorganic components that provides mechanical strength and stability to the structure (Dorozhkin, 2013). The organic components include fat, collagenous, and non-collagenous proteinthat are packed together with inorganic nano-hydroxyapatite (nano-HAp) to form a bone structure(Poinern et al, 2016). Nano-Hap with achemical formula of Ca10 (PO4)6(OH) is an organic mineral component found in bone and teeth which 251 possesses excellent biological properties (Barakat et al, 2009; Jahan et al, 2017). Nano-HAp has many applications in medical, pharmaceutical, and dentistry due to its enhanced biocompatibility, bioactivity, non-inflammatory behavior, non-immunogenicity and high osteoconductive properties (Giraldo-Betancur et al, 2013; Huang and Chu, 2013). Nano-Hap fulfilled the required criteria to be applied in most medical and dentistry purposes related to living things due to its excellent biocompatibility
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