Nitrogen mustard therapy complicated by acute renal failure due to uric acid crystallization.

Abstract

Case Reports1 December 1953NITROGEN MUSTARD THERAPY COMPLICATED BY ACUTE RENAL FAILURE DUE TO URIC ACID CRYSTALLIZATIONGLENN H. RICHMOND, GRANT D. BEARDSLEYGLENN H. RICHMONDSearch for more papers by this author, GRANT D. BEARDSLEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-6-1327 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the first clinical use of nitrogen mustard compounds in 1942,1hundreds of articles have appeared in the medical literature to attest its value in the palliative therapy of Hodgkin's disease, lymphosarcoma, chronic leukemia and other neoplastic diseases. The narrow margin between the toxic and the therapeutic dose is shown by the occurrence of toxicity in almost every case treated effectively. It has been generally accepted that toxicity is a necessary accompaniment of effective therapy, and the literature on this subject has been limited. The pharmacologic activities of the nitrogen and sulfur mustards have been excellently presented by Gilman and...Bibliography1. GilmanGoodmanLinskogDougherty ALGEJ, 1942-1943, quoted in Gilman, A., and Philips, F. S.2 Google Scholar2. GilmanPhilips AFS: The biological actions and therapeutic application of β-chloroethyl amines and sulfides, Science 103: 409-415 (Apr. 5) 1946. CrossrefGoogle Scholar3. Mills ES: Nitrogen mustard—a dangerous therapeutic agent, Tr. A. Am. Physicians 64: 392-403, 1951. MedlineGoogle Scholar4. KurnickPaleyFieberAdler NBKRMHDK: Treatment of malignant disease with nitrogen mustard, Ann. Int. Med. 30: 974-1003 (May) 1949. LinkGoogle Scholar5. MerrillJackson DH: The renal complications of leukemia, New England J. Med. 228: 271-275 (Mar. 4) 1943. CrossrefGoogle Scholar6. LearOppenheimer HGD: Anuria following radiation therapy in leukemia, J. A. M. A. 143: 806-807 (July 1) 1950. CrossrefMedlineGoogle Scholar7. KravitzDiamondCraver SCHDLF: Uremia complicating leukemia chemotherapy, J. A. M. A. 146: 1595-1597 (Aug. 25) 1951. CrossrefMedlineGoogle Scholar8. Karnofsky DA (Memorial Hospital, Center for Cancer and Allied Diseases): Personal correspondence. Google Scholar9. PetersVan Slyke JPDD: Quantitative clinical chemistry interpretations, vol. 1, 1946, The Williams & Wilkins Co., Baltimore, pp. 949-987. Google Scholar10. Butt AJ: Role of protective urinary colloids in prevention of renal lithiasis, J. Urol. 67: 450-459 (Apr.) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC Tacoma, Washington*Received for publication May 27, 1953.From the General Medical Section, Madigan Army Hospital, Tacoma, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmergencies in haematology: tumour lysis syndromeSurgery With Impaired Renal Function: Basic ConsiderationsAkutes NierenversagenSPECIAL PROBLEMS IN TOXICITYUse of Mannitol in Exogenous and Endogenous IntoxicationsRenal complications of neoplastic diseaseOliguric Renal Failure and Acute Tubular NecrosisEtiological Factors in Urolithiasis: A Clinical Analysis of 275 CasesUric Acid Stones: A Study of 58 PatientsUrinary Uric Acid Excretion in LeukemiaDiseases of Medical ProgressZytostatikaZytostatika 1 December 1953Volume 39, Issue 6Page: 1327-1332KeywordsAcute renal failureHodgkin lymphomaLymphocytic leukemiaPalliative careToxicityUric acid ePublished: 1 December 2008 Issue Published: 1 December 1953 PDF downloadLoading ...