Abstract
The furan nucleus may be considered as a latent 1,4-dicarbonyl group. Expression of this functional equivalence within a generic 2-furylamide results in formation of nitrogen heterocycles in a reaction that may be termed the "Aza-Achmatowicz rearrangement", by analogy with similar transformations of furylcarbinols. Aza-Achmatowicz products may be created in enantioselective form by chemoenzymatic methods, and are useful intermediates in the synthesis of novel carbacephems, unusual aminoacids, azasaccharides, piperidine and izidine alkaloids. This Account reviews the most significant aspects of aza-Achmatowicz chemistry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
