Abstract
As shown by 1H, 13C, and 15N n.m.r. spectroscopy, protonation of 9-formyltetrahydropyrido[1,2-a] pyrimidin-4-ones takes place at the formyl oxygen atom. As a result, the enamine tautomer, predominant in the base form, is transformed into a protonated enolimine tautomer having an exocyclic double bond. 15N N.m.r. shifts reflect not only the state of the tautomeric equilibria but also the state of Z/E isomerism and the effect of remote substituents.
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