Abstract
In 1968, Joseph Sachs et al. published a report in the New England Journal of Medicine on urinary concentrations of nitrofurantoin after its oral administration to an unspecified number of hospitalized individuals, some of whom required treatment for active urinary tract infection [1]. Recovery of nitrofurantoin from the urine appeared to be linearly related to creatinine clearance. In ‘uraemic’ individuals, whose creatinine clearances were not reported, the highest nitrofurantoin concentrations reached were considered probably too low to inhibit the growth of uropathogens, although neither MICs nor microbiological or clinical outcomes were reported.
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