Abstract
This review explores the interaction between nitric oxide-derived reactive species and unsaturated fatty acids, leading to the formation of electrophilic nitroalkenes, named nitro-fatty acids (NO2-FA). These species serve as endogenously produced anti-inflammatory signaling mediators, demonstrating protective effects in pre-clinical animal disease models. The discussion herein focuses on the cell signaling actions of NO2-FA, drawing insights from both existing knowledge and recent in vivo data. Additionally, this review addresses the potential pharmacological utility of NO2-FA and ongoing trials, highlighting their promising prospects based on the gathered information.
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