NITRITE AND NITRATE ION DISTRIBUTION IN BLOOD OF MEN FROM GOMEL REGION DEPENDING ON ONCOMARKER CONCENTRATION (PROSTATE SPECIFIC ANTIGEN, CANCER ANTIGEN 19-9, СARCINOEMBRYONIC ANTIGEN AND ALPHA FETOPROTEIN)

Abstract

Nitrite and nitrate ions are major nitrogen monoxide (NO) metabolites in the organism. NO and its derivatives including peroxynitrite and nitrogen dioxide can be pro- and anticancer factors depending on their concentration. The work aimed at specifying the parameters of NO metabolite concentration distribution in blood plasma of men from Dobrush district of Gomel region depending on blood oncomarker level (prostate specific antigen (PSA), cancer antigen 19-9, сarcinoembryonic antigen and alpha-fetoprotein). It was revealed that the distribution of NO metabolite concentration could be approximated by two Gauss’ functions (R 2 > 0.98). This corresponded to the presence of two groups of men with different NO production rate. For control population in which the men with low oncomarker level were included, NO metabolite concentration in 10 % of men was two-fold higher than the concentration that was characteristic of the rest 90 % of men. When the concentration of one or more oncomarkers increased the probability of transition from the state with low NO concentration to the state with high NO concentration was increased. Inverse correlation between PSA oncomarker and NO metabolite concentration in plasma was revealed. The obtained results are an evidence of a complex interlacement between the mechanisms of NO synthesis and carcinogenesis. The possible use of plasma NO metabolite level as an additional marker for the refinement of diagnosis and prognosis of carcinogenesis were discussed.