Abstract
The fundamental role of nitric oxide (NO) in the maintenance of normal human physiology and the attendant pathology resultant from its perturbation in disease states is becoming increasingly apparent. That NO mediates such diverse functions as maintenance of volume and pressure homeostasis, neurotransmission, and immunity is not surprising given its primordial origins. NO synthesis has been detected in species as diverse as slime mould, locusts, and man. This article will review the structure and regulation of the nitric oxide synthases and discuss selected aspects of the role of NO in human health and disease. The reader is referred to excellent recent reviews for more detailed discussions [1,2].
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