Abstract
There are three isoforms of nitric oxide synthase (NOS), named according to their activity or the tissue type in which they were first described: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). nNOS and eNOS are two constitutive isoforms and iNOS is the induced, more persistent one. The three NOSs catalyze the formation of citrulline and nitric oxide (NO) from L-arginine (L-Arg), NADPH, and O2. Adhesion fibroblasts exhibit a significant reduction in NO levels, although there was no difference in mRNA and protein levels of iNOS between normal peritoneal and adhesion fibroblasts.
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