Abstract
Surface graft polymerization with poly(ethylene glycol) acrylate is reported as an effective method for modifying the surface of poly(dimethylsiloxane) array templates thus enabling the preparation of nitric oxide (NO)-releasing xerogel micropatterns. The surface wettability of PEGA-grafted templates was sufficient to overcome the flow resistance of ethyltrimethoxysilane (ETMOS) sol solutions and allow the formation of xerogel microarrays via capillary action of sol through the template channels. Due to the combined versatility of both sol−gel chemistry and micropatterning, substrates were modified with a range of aminosilane-doped xerogel microarrays with variable NO release properties. Several parameters were studied including (1) NO surface flux as a function of type and concentration of aminosilane NO-donor precursor; (2) micropattern dimensions for maximizing surface flux and duration of NO release; and (3) the effect of microstructure separation on localized NO surface concentration as determined wi...
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