Abstract
Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.
Highlights
Nitric oxide (NO) is an important cell-signaling molecule whose role in a variety of cellular processes, such as vascular relaxation[1,2,3,4], neurotransmission, platelet aggregation and immune regulation[5]
The main component of Natural rubber latex (NRL) is cis-1,4-polyisoprene with a high degree of long chain branching generally associated with the presence of non-hydrocarbon groups distributed along the chains
One of the most important of the non-hydrocarbon group’s presents in NRL is the aldehyde group, which is thought to be responsible for crosslinking between the chains in NRL27 and their concentration varying from clone to clone[28]
Summary
Nitric oxide (NO) is an important cell-signaling molecule whose role in a variety of cellular processes, such as vascular relaxation[1,2,3,4], neurotransmission, platelet aggregation and immune regulation[5]. Natural rubber latex (NRL, cis-1,4-polyisoprene) extracted from Hevea brasiliensis has been widely used as raw material in the manufacturing of gloves, condoms, balloons, and other medical and dental devices For those applications, the processing of NRL was basically the same as those found in the tires industry. Nitric oxide (NO) is an important physiological cellular signaling molecule that functions in a diverse range of cellular processes playing many biological roles as a major defense molecule against intercellular bacteria, tumor cells and aiding in wound repair. We propose a NO release system based on the encapsulation of FeDETC in a NRL matrix for the sustained and controlled delivery of NO for future applications in medicine as wound healing. To characterize the release behavior of NO by this system, the NRL-FeDETC system was exposed to ambient atmosphere (humidity 60%, 25 °C) and the EPR signal of NO in the membrane was monitored as function of time
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