Abstract
Murine macrophages produce large amounts of nitric oxide (NO) on stimulation by interferon (IFN)-γ and lipopolysaccharide (LPS) or a high concentration of LPS alone. Agents which increase intracellular cAMP levels inhibit cytokine production by macrophages. The effect of increased intracellular cAMP levels on NO production was investigated, using a murine inacrophage cell line, J774. NO production was reduced by prolonged elevation of cAMP, but not by a transient increase.
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