Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis.

Jingdong Rao,Ho Pan Bei,Yu Liu,Xin Zhao,Yuhe Yang,Haodong Lin

doi:10.3389/fbioe.2020.00578

Abstract

Cardiovascular stenting is an effective method for treating cardiovascular diseases (CVDs), yet thrombosis and restenosis are the two major clinical complications that often lead to device failure. Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performance of cardiovascular stents thanks to its anti-thrombosis and anti-restenosis ability, but its short half-life limits the full use of NO. To produce NO at lesion site with sufficient amount, NO-producing coatings (including NO-releasing and NO-generating coatings) are fashioned. Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy utilizes the in vivo substances such as S-nitrosothiols (RSNOs) to generate NO flux. NO-producing stents are particularly promising in future clinical use due to their ability to store NO resources or to generate large NO flux in a controlled and efficient manner. In this review, we first introduce NO-releasing and -generating coatings for prevention of thrombosis and restenosis. We then discuss the advantages and drawbacks on releasing and generating aspects, where possible further developments are suggested.

Highlights

Cardiovascular diseases (CVDs) are a common cause of morbidity worldwide, accounting for 18 million deaths per year, and serve as a third of all global deaths (Frieden and Jaffe, 2018; Yusuf et al, 2020)
The immobilized enzyme retained the catalytic property up to 1 month in vivo and the results revealed effective inhibition of thrombosis and enhancement of vascular tissue regeneration and remodeling in enzyme prodrug therapy (EPT) group
The progress of the Nitric oxide (NO)-producing stent coatings are highly inspiring in the prevention of thrombosis and restenosis, and researchers have attempted to improve the fabrication process and committed to developing simple materials for future clinical application

Summary

Introduction

Cardiovascular diseases (CVDs) are a common cause of morbidity worldwide, accounting for 18 million deaths per year, and serve as a third of all global deaths (Frieden and Jaffe, 2018; Yusuf et al, 2020). We first introduce NO-releasing and -generating coatings for prevention of thrombosis and restenosis. Zhao X (2020) Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis.

Results

Conclusion