Abstract
PURPOSE: Sepsis is associated with numerous hemodynamic complications, including alterations in microvascular permeability. A study by Christ, et al. (Intensive Care Med 1998; 24:18–27) demonstrated enhanced capillary filtration coefficient (Kf) in patients with septic shock. Sepsis is associated with neutrophil activation and increased levels of plasma nitrites/nitrates (NOx). We hypothesized that nitric oxide (NO) and activated neutrophils have a causal role in the permeability alterations in sepsis and thus anticipated significant correlations between Kf and one marker of neutrophil activation (alpha 4 integrin) and nitric oxide activity (as measured by neutrophil iNOS activity and plasma NOx concentration).
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