Abstract
Systematic optimization of the aza-BODIPY dye platform facilitated planarization and a red-shift in the absorbance. SR-APNO-3 enabled the first validated detection of cancer-derived nitric oxide with PA imaging.
Highlights
Reactive oxygen and nitrogen species represent a major class of biological signaling molecules
Nitric oxide (NO) is a key signaling molecule involved in a variety of physiological and pathological processes
We report the optimization of an activatable photoacoustic probe for NO by planarizing the boron-azadipyrromethene dye platform via steric relaxation
Summary
Reactive oxygen and nitrogen species represent a major class of biological signaling molecules. We report the optimization of an activatable photoacoustic probe for NO by planarizing the boron-azadipyrromethene (aza-BODIPY) dye platform via steric relaxation.
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