Nitric Oxide and the Ryanodine Receptor Ca-Release Channel

Abstract

To the Editor: I have read with interest the recent review on the role of S -nitrosylation in cardiovascular signaling, in which Lima et al1 provide a very useful digest on the current status of research in this important but burgeoning field of cardiovascular physiology. On the other hand, I believe that one of the many functions of a scientific review, especially when summarizing the status of a field with a certain degree of ambiguity, is to promote further progress. This is, perhaps, best achieved if all the available data relevant to the field are summarized and discussed, even those that seem to be contradictory to the intended conclusion of the review. Although the review in question cites almost 200 works, it …