Abstract
Background The signaling molecule nitric oxide (NO) is known to activate the enzyme NO-sensitive guanylyl cyclase (NOGC). By generation of the intracellular second messenger cGMP NO-GC regulates many physiological processes. In the gastrointestinal (GI) tract nitrergic neurons are part of the enteric nervous system which regulates GI motility. In addition, interstitial cells of Cajal (ICC) are thought to be involved in nitrergic relaxation. In this study, we intended to clarify the role of NO-GC regarding GI motility in mice by using cellspecific knockout strains.
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