Abstract
AbstractNanomotors are appealing drug carriers, and the strength of the propelling force is important for their motion capability. Though high motion efficiency has been achieved with 808 nm light driven Janus‐structured noble metal nanomotors, the NIR‐I light penetration depth and material biocompatibility limit their broad application. Herein, we develop a 1064 nm NIR‐II light driven asymmetric hydrogel nanomotor (AHNM) with high motion capability and load it with doxorubicin for enhanced immunochemotherapy. Magnetic field assisted photopolymerization generates an asymmetric distribution of Fe3O4@Cu9S8 nanoparticles in the AHNM, producing self‐thermophoresis as driving force under NIR‐II irradiation. The AHNM is also functionalized with dopamine for the capture and retention of tumor‐associated antigens to boost immune activation. The as‐obtained NIR‐II light driven AHNM has a high tumor tissue penetration capability and enhances immunochemotherapy, providing a promising strategy for cancer therapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.