NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion

Abstract

AbstractMedical implants are widely used in clinical practice, such as cardiovascular stenting, maxillofacial surgery, and orthopedics. However, most of the traditional implant operations are open and invasive, resulting in massive dissection of soft tissue and interruption of blood supply. The accurate navigation for the implant operations is considered as one of the most effective ways to reduce the damage, which is urgently desired in clinic. Herein, a biocompatible NIR‐II J‐aggregates labelled mesoporous implant for imaging‐guided osteosynthesis with minimal invasion is reported. Mesoporous silica layer with vertical channels is grown on the surface of titanium plate, which can provide the confining space for the formation of the FD‐1080 J‐aggregates. Both the absorption and fluorescence peaks of the FD‐1080 J‐aggregates are located in NIR‐II window (beyond 1300 nm), which are ideal for high resolution and real time surgical navigation in deep tissue. NIR‐II imaging can clearly display the location and outline of the implant both in vitro and in vivo. This NIR‐II imaging‐guided osteosynthesis can effectively reduce the surgical wound and operational duration, which is crucial for the implant surgeries.