Abstract
Photodynamic therapy (PDT) as an appealing modality has been used to treat various malignant tumours. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for deep-seated tumor. To address these obstacles for PDT treatment, we firstly used aza-indole to modify pentamethine dyes to facilitate a large bathochromic shift of the absorption maximum from 650 nm to 730 nm in the photo-therapeutic window. Interesting, BY-Br have higher molar extinction coefficient than BY-H, allowing BY-Br to absorb more light for enhance its therapeutic effect. Meanwhile, the introduction of bromine atoms has been enhanced reactive oxygen species generation (ROS) after laser irradiation. Furthermore, the new photosensitizer, BY-Br could specifically target to mitochondria, and substantial kill tumor cells through apoptotic pathway upon irradiation.
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