Abstract
In this work, a near-infrared CCD-based singlet oxygen luminescence two-dimensional imaging method is proposed to detect singlet oxygen by its 1270nm luminescence. Two-dimensional singlet oxygen images with its near-infrared luminescence during photosensitization could be obtained with a CCD integration time of 1s, without scanning. The data presented shows a linear relationship between the singlet oxygen luminescence intensity and sample concentration. This method provides a detection sensitivity of 0.00189mg/ml (Hematoporphyrin monomethyl Ether dissolved in ethanol) and a spatial resolution better than 100μm. We applied this method in vivo to demonstrate its potential in monitoring photodynamic therapy.
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