NIR-Activated Polydopamine-Coated Carrier-Free "Nanobomb" for In Situ On-Demand Drug Release.

Minghui Li,Yang Yang,Huizhen Jia,Wenguang Liu,Ning Zhang,Xuetan Sun,Wei Wang

doi:10.1002/advs.201800155

Abstract

Carrier‐free nanoparticles with high drug loading have attracted increasing attention; however, in situ on‐demand drug release remains a challenge. Here, a novel near‐infrared (NIR) laser‐induced blasting carrier‐free nanodrug delivery system is designed and fabricated by coating doxorubicin (DOX) nanoparticles (DNPs) with a polydopamine film (PDA) that would prolong the blood circulation time of DNPs and avoid the preleakage of the DOX during blood circulation. Meanwhile, the NH4HCO3 is introduced to trigger in situ “bomb‐like” release of DOX for the production of carbon dioxide (CO2) and ammonia (NH3) gases driven by NIR irradiated photothermal effect of PDA. Both in vitro and in vivo studies demonstrate that the carrier‐free nanovectors with high drug loading efficiency (85.8%) prolong tumor accumulation, enhance chemotherapy, achieve the synergistic treatment of chemotherapy and photothermal treatment, and do not induce any foreign‐body reaction over a three‐week implantation. Hence, the delicate design opens a self‐assembly path to develop PDA‐based NIR‐responsive multifunctional carrier‐free nanoparticles for tumor therapy.

Highlights

Carrier-free nanodrugs have been reported to improve the drug loading efficiency and avoid the side effects of and photothermal treatment, and do not induce any foreign-body reaction inert materials introduced
The carrier-free nanodrugs were prepared by reprecipitation method
Thereafter, PDA coating was introduced into the DNPs nanosystems containing NH4HCO3 via an oxidative self-polymerization of dopamine under a weakly alkaline solution and shaking at room temperature overnight based on the fact that the PDA film can attach onto the surface of a wide range of materials including organic and inorganic.[19]