Abstract
The dense extracellular matrix (ECM) and internal fluid pressure (IFP) seriously alter the effective delivery of nanodrugs in tumour tissue. In order to solve this problem, a photothermal driven nanomotor was designed (PB@ZIF-8@TPZ, PZT), performing the function of “four in one” on the premise of minimum composition. The nanomotor can simultaneously realise PTT/CDT/hypoxia-activation-CT, GSH consumption and photothermal-driven, among which prussian blue (PB) was first found to be able to simultaneously realise photothermal-driven, GSH consumption and PTT/CDT’s “four in one” function. Nanomotor has the advantages of good stability, low cost, easy synthesis, excellent ability for deep puncture and a high anti-tumour effect.
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