Abstract
The hypolipidemic action of NIP-200, 3, 5-dimethyl-4, 6-diphenyl - tetrahydro-2H-1, 3, 5-thiadiazine-2-thione, was studied in three models of cholesterol-fed rats. In lipids emulsion-induced hyperlipidemic rats, oral administration of 300mg/kg of NIP-200 for 3 days lowered serum total cholesterol by 48% and elevated HDL-cholesterol by 36%. NIP-200 showed no significant effect on serum triglyceride. In the prevention study on cholesterol-fed rats, oral administration of NIP-200 for 14 days decreased serum total cholesterol, free cholesterol and phospholipid in a dose dependent manner, and moreover elevated HDL-cholesterol at all doses. NIP-200 decreased liver total cholesterol by 16% at 150mg/kg, but showed no effect on other doses. The hypolipidemic effect of NIP-200 was considered to be about two to three times as great as that of clofibrate. In the treatment study on cholesterol-fed rats, oral administration of 300mg/kg of NIP-200 for 7 days decreased serum total cholesterol and triglyceride by 44% and 48%, respectively, and increased HDL-cholesterol by 48%.
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