Abstract
Niosomes are vesicles, which are formulated by hydrating the mixture of cholesterol, non-ionic surfactant and other biodegradable lipids. Niosomes increase the drug activity as compare to their conventional dosage form of a drug. Niosomes can be used as carrier of amphiphilic and lipophilic drugs. Niosomes may overcome the issues related to instability, fast degradation, low bioavailability, and insolubility of medications. The structure of niosomes either multilamellar or unilamellar, is depends on the method of formulation. Niosomes contain very efficient drug delivery potential for site-specific delivery of anti-cancer, anti-infective agents, etc. Niosomes are stable as well as cost effective carriers as compared with other drug formulations. Niosomes also have various applications in parental drug delivery system, topical drug delivery system, oral drug delivery system and novel drug delivery system such as targeted drug delivery system and controlled drug release system.
Highlights
Delivery with controlled release kinetics of drug in desire manner
The method of Hand stirring is similar to the methods of thin film hydration, this method forms Multilamellar vesicles (MLV), in this method additives and surfactant are dissolved in organic solutions that are evaporated by rotary evaporator to form a thin film, after which this dry thin layer is mixed with an aqueous one hydrated solution. drug containing as PBS pH = 7.4; Shake this mixture for 1 hour with mechanical stirring to form niosomes [18]
Niosomes are act as haemoglobin carriers: Niosomes are used for the delivery of proteins peptide drugs (PPD)
Summary
Delivery with controlled release kinetics of drug in desire manner. The present conventional dosage Nowadays, there is no chance of any available form often have side effects and complication drug delivery model to achieve the site-specific. The formation of vesicle aggregates requires some energy input, and all the preexperimental methods studied involve hydrating the surfactant mixture on the gel at the liquid transition temperature of the system and reducing the size to obtain a colloidal dispersion. Due to their potential ability to deliver various therapeutic agents, these vesicles are widely used as drug delivery systems to achieve targeted drug delivery, controlled release, and improved permeability. Drug ionization has been shown to adjust the physical and chemical properties of vesicles and their percutaneous penetration curve; in the past few decades, niosomes have been widely studied as potential carriers for sustained and targeted drug delivery because they can reprivatisation to increase the versatility of the vesicles and the correct affinity for the target site [4]
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