Abstract
BackgroundLeprosy is a chronic granulomatous infection caused by Mycobacterium leprae, the obligate intracellular bacillus that attacks cutaneous tissue and can damage the peripheral nervous system. AimTo determine the association between the Ninjurin 1 gene asp110ala (rs2275848) polymorphism in nerve damage leprosy patients. Meterials and methodsWe carried the 234 leprosy patients along with equal number of controls with age and gender-matched were recruited. Genotyping was done by polymerase chain reaction/restriction fragment length polymorphism and confirmation of sequence. ResultsThe CC genotype (ala/ala) had a higher risk of developing nerve disability when compared those carrying the AA genotype (asp/asp) and the variation observed were statistically significant at P<0.05. ConclusionThe Ninjurin 1 gene asp110ala genetic variation may be a risk of nerve damage among leprosy patients in south India.
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