Nine insights from internet engineering that help us understand brain network communication

Abstract

Philosophers have long recognized the value of metaphor as a tool that opens new avenues of investigation. By seeing brains as having the goal of representation, the computer metaphor in its various guises has helped systems neuroscience approach a wide array of neuronal behaviors at small and large scales. Here I advocate a complementary metaphor, the internet. Adopting this metaphor shifts our focus from computing to communication, and from seeing neuronal signals as localized representational elements to seeing neuronal signals as traveling messages. In doing so, we can take advantage of a comparison with the internet's robust and efficient routing strategies to understand how the brain might meet the challenges of network communication. I lay out nine engineering strategies that help the internet solve routing challenges similar to those faced by brain networks. The internet metaphor helps us by reframing neuronal activity across the brain as, in part, a manifestation of routing, which may, in different parts of the system, resemble the internet more, less, or not at all. I describe suggestive evidence consistent with the brain's use of internet-like routing strategies and conclude that, even if empirical data do not directly implicate internet-like routing, the metaphor is valuable as a reference point for those investigating the difficult problem of network communication in the brain and in particular the problem of routing.