Abstract
There is a high mortality rate in Stevens Johnson Syndrome (SJS) and it ranges between 5%-15%. At present, there is no definite consensus regarding treatment in SJS although the effectiveness of intravenous immunoglobulin’s (IVIg) and immunosuppressive like cyclosporine have generated new hopes in the lives of these patients. But the options of combination therapy of steroids, IVIg and Placentrex gel have not been fully exercised in SJS. Henceforth, we report a case of Nimesulide induced SJS; managed successfully with a combined approach without any recurrence during a 12 months follow-up.
Highlights
Stevens-Johnson syndrome (SJS) is a rare and life threatening form of severe cutaneous adverse drug reaction (SCAR) having an unpredictable lethal course in 5-15 % of the cases [1]
Immunological mechanisms involved in the causation of SJS are by inducing apoptosis of keratinocytes by the releasing cytokines such as IL-6, TNF- α and CD95 system through death receptors (CD 95RL/FasL, CD 95R/Fas)
These receptors are a group of glycoproteins within keratinocytes which binds with Fas ligand (Fas-L) initiating apoptosis through caspases leading to DNA disassembly and cell death [8]
Summary
Stevens-Johnson syndrome (SJS) is a rare and life threatening form of severe cutaneous adverse drug reaction (SCAR) having an unpredictable lethal course in 5-15 % of the cases [1]. Nimesulide induced Stevens Johnson syndrome (SJS); managed successfully with combined approach of steroids, intravenous immunoglobulin and placentrex gel: A case report. Introduction Stevens-Johnson syndrome (SJS) is a rare and life threatening form of severe cutaneous adverse drug reaction (SCAR) having an unpredictable lethal course in 5-15 % of the cases [1].
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