Abstract
There are reports regarding the up-regulation of cyclooxygenase isoenzyme particularly inducible isoform i.e. COX-2 in brain during neurodegenerative or neuropsychiatric disorders. In the present study, we examined the effect of nimesulide (a preferential COX-2 inhibitor) in subchronic immobilization stress. Mice were subjected to immobilization stress for 6 hrs daily for a period of seven days. Nimesulide (2.5 mg/kg, i.p.) was administered daily for 7 days before challenging them to immobilization stress. Behavioral analysis revealed the hyperlocomotor activity and increased anxious response. Subchronic stress decreased % retention of memory and also caused hyperalgesic response in mice. Biochemical analysis revealed that chronic immobilization stress significantly increased lipid peroxidation and nitrite levels and decreased the reduced glutathione and adrenal ascorbic acid levels. Chronic treatment with nimesulide significantly attenuated the immobilization stress-induced behavioral and biochemical alterations. These results suggested that the use of nimesulide could be a useful neuroprotective strategy in the treatment of stress.
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