NIH Grant Watch

Abstract

BioTechniquesVol. 45, No. 3 NIH Grant WatchOpen AccessNIH Grant WatchK. Nybo† & B. Perry††K. Nybo††is assistant editor at BioTechniques.Search for more papers by this author & B. Perry††††is president of NIH Sales, Rockville, MD.Search for more papers by this authorPublished Online:16 May 2018https://doi.org/10.2144/000112941AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInRedditEmail Self-assembling Peptides; Non-invasive Optical Brain ImagingBioTechniques and NIH Sales reviewed grants made by the National Institutes of Health during the last 30 days. Here are some highlights from among the largest 100 R01 and R03 grants awarded during July 2008.Self-assembling Peptides for Tissue Engineering $1,348,457(5R01EB003805-04, National Institute of Biomedical Imaging and Bioengineering) Alan Grodzinsky (Massachusetts Institute of Technology, Cambridge, MA)Goal: To design functional self-assembling peptide sequences for 3-D tissue engineering, measure and model the biophysics of the peptide self-assembly environment, and explore these environments in myocardium, cartilage, and liver. Experts in electrical, mechanical, and chemical engineering will collaborate with chemists, biologists, and clinical scientists to complete these aims.Non-invasive Optical Imaging of Neuropathology In Vivo $800,811(5R01AG026240-03, National Institute on Aging)Brian Bacskai (Massachusetts General Hospital, Boston, MA)Goal: To improve optical imaging techniques and generate novel contrast reagents for near-infrared molecular imaging. The multidisciplinary program includes advancement of the hardware and software of an existing optical imaging system and development of molecular imaging probes that target specific intracranial structures for in vivo imaging of neurological disease.Whole-genome Shotgun Sequencing Strategy and Assembly $759,485(5R01HG003474-04, National Human Genome Research Institute)David Jaffe (Massachusetts Institute of Technology, Cambridge, MA)Goal: To produce better quality genome sequences at lower cost by improving assembly of whole-genome shotgun sequencing data. This program will optimize strategy selection criteria for sequencing new organisms, develop algorithms for more accurate and complete genome assembly, and implement strict tests to maintain internal consistency.Molecular Analysis of Hotspots of Genetic Recombination $749,889(5R01GM031693-26A2, National Institute of General Medical Sciences)Gerald Smith (Fred Hutchinson Cancer Research Center, Seattle, WA)Goal: To understand the mechanism and regulation of recombination along chromosomes and across lifespan. This will be accomplished by studying hotspots of recombination in Escherichia coli and Schizosaccharomyces pombe to determine the proteins involved in recombinant structure formation and their interactions and to assess the roles of chromatin modifications in regulating recombination sites.The following six grants were awarded for the development of databases or software that may become valuable research tools for those working in the biosciences:Yeast Genetic Interaction Map $1,410,493(5R01HG002432-06, National Human Genome Research Institute)Jef Boeke (Johns Hopkins University, Baltimore, MD)Building a Framework for Exploration of Orthologs and Evolutionary Distances $84,500(5R03LM009261-02, National Library of Medicine)Dennis Wall (Harvard University Medical School, Boston, MA)Gene Expression Database for Mouse Development $1,017,606(5R01HD033745-11, National Institute of Child Health and Human Development)Martin Ringwald (Jackson Laboratory, Bar Harbor, ME)Comparative Toxicogenomics Database (CTD) $854,606(5R01ES014065-03, National Institute of Environmental Health Sciences)Carolyn Mattingly (Mount Desert Island Biological Lab, Salisbury Cove, ME)Dissemination of Cross-platform Software for Artifact Detection and Region of Interest $162,238(1R03EB008673-01, National Institute of Biomedical Imaging and Bioengineering)Satrajit Ghosh (Massachusetts Institute of Technology, Cambridge, MA)FiguresReferencesRelatedDetails Vol. 45, No. 3 Follow us on social media for the latest updates Metrics Downloaded 97 times History Published online 16 May 2018 Published in print September 2008 Information© 2008 Author(s)PDF download