Abstract
The effects of morphine on nigrostriatal neurons (substantia nigra and caudate nucleus) were examined in mice of two strains (C58 and DBA), which differ in their locomotor response to morphine. The results did not support the hypothesis that the differences in locomotor response to morphine between the two strains are paralleled by differences in the response of nigrostriatal neurons to the same drug. The general effect of morphine on nigrostrial neurons, irrespective of strain, was to markedly depress their firing rate. Some nigrostriatal neurons initially speeded up but this effect was strain independent. This same general pattern was observed in some neurons recorded within the reticular formation. The results are discussed in relationship to the current concepts of morphine action on dopaminergic systems and the role of the nigrostriatal system in locomotor control.
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