Abstract
Convincing lawmakers of the importance of basic science can be a hard sell, but officials at the National Institutes of Health’s National Institute of General Medical Sciences (NIGMS) have excelled at it for the past 50 years. Authorized by Congress in 1962 to support research and training in general or basic biomedical sciences, NIGMS is one of the largest institutes in terms of budget at NIH. From the beginning, NIGMS has supported fundamental research on how life works at the most basic level. Numerous significant medical breakthroughs have resulted from that research, including new ways to detect, treat, and prevent disease. In the late 1960s and early ’70s, the institute funded the basic science on restriction enzymes that led to recombinant DNA technology and genetic engineering. More recently, NIGMS has supported studies that catalyzed the fields of pharmacogenomics, protein structure analysis, cellular imaging, computational biology, stem cell biology, and RNA ...
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