Night-time right hemisphere superiority and daytime left hemisphere superiority: A repatterning of laterality across wake–sleep–wake states

Abstract

During the sleep onset period (SOP), there is a state-specific relative advantage of the right hemisphere (RH). This superiority could either be due to the ability of the RH when operating at levels of reduced arousal, as suggested by its superiority in sustaining vigilance, or it could depend on a more pronounced homeostatic deactivation of the left hemisphere (LH). To evaluate whether variations of lateralization from wake to sleep are consistent with one of these two hypotheses, we considered a finger tapping task (FTT) bimanually performed during two wakeful conditions, during the SOP, upon experimental awakenings from stage 2 and REM sleep in the first and in the second part of the night, and upon morning awakening. The RH advantage in sustaining vigilance would be supported if the relative RH advantage was present throughout the sleep period. Finding that the repatterning of hemispheric asymmetry is present and/or prominent in the first part of the night would support the homeostatic hypothesis, i.e. when the homeostatic process is more pronounced. Results from 16 subjects revealed a significant superiority of the LH during the two wakeful conditions. At sleep onset, a clear reversal of dominance was observed and it was followed by a steady RH superiority upon both REM and NREM sleep awakenings, and upon the morning sleep–wake transition. Therefore, performance in a FTT reveals a repatterning of laterality across wake–sleep–wake states. These results are interpreted as consistent with the hypothesis concerning an advantage of the RH in sustaining vigilance.