Abstract
BackgroundNight shift work surrounding pregnancy may contribute to the risk of developing atopic diseases in offspring due to alterations in the prenatal environment, from stress.ObjectiveTo examine the association of maternal night shift work surrounding pregnancy and offspring risk of developing atopic diseases from childhood to adolescence.MethodsWe examined the association between night shift work before and during pregnancy among 4,044 mothers in the Nurses’ Health Study II (NHSII) and atopic dermatitis, asthma and hay fever risk in 4,813 of their offspring enrolled in the Growing Up Today Study (GUTS). Mothers reported whether GUTS participants had ever been diagnosed with atopic dermatitis, asthma or hay fever in the GUTS Mothers’ questionnaire. Generalized estimating equation regression models were used to estimate multivariable adjusted odds ratios (OR) and 95% confidence intervals (CIs).ResultsThere were no significant associations between pre-conception maternal night shift work and risk of atopic dermatitis, asthma or hay fever in their offspring. Among 545 mothers with information on night shift work during pregnancy, shift work also was not associated with atopic dermatitis, asthma or hay fever in the offspring. Stratified analyses by history of parental atopy and maternal chronotype showed some statistically significant findings, but they were inconsistent and no significant interaction was seen with increasing duration of night shift work.ConclusionIn this study, night shift work before and during pregnancy did not increase offspring risk of developing atopic dermatitis, asthma or hay fever.
Highlights
Atopic diseases such as atopic dermatitis (AD), asthma and hay fever are among the most common chronic conditions in childhood and often coexist in the same individual [1,2]
We examined the association between night shift work before and during pregnancy among 4,044 mothers in the Nurses’ Health Study II (NHSII) and atopic dermatitis, asthma and hay fever risk in 4,813 of their offspring enrolled in the Growing Up Today Study (GUTS)
There were no significant associations between pre-conception maternal night shift work and risk of atopic dermatitis, asthma or hay fever in their offspring
Summary
Atopic diseases such as atopic dermatitis (AD), asthma and hay fever are among the most common chronic conditions in childhood and often coexist in the same individual [1,2]. Previous studies suggest there may be an “atopic march;” that these atopic manifestations progress sequentially beginning with AD and leading to asthma and/or hay fever [3,4]. AD is a common inflammatory skin disease that usually begins in childhood, with a prevalence of 20% in children worldwide [5]. Dermatitis is accountable for the largest global burden of disability-adjusted life years (DALYS) and morbidity (Years Lived with Disability) [7]. Night shift work surrounding pregnancy may contribute to the risk of developing atopic diseases in offspring due to alterations in the prenatal environment, from stress
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