Abstract
In this era, various traditional medicinal herbs were researched for their toxicological and safety aspects. The present study focused on using Nigella sativa fixed (NSFO) and essential oil (NSEO) to mitigate the adverse consequences of oxidative stress. For the purpose, oxidative stress was induced in Sprague Dawley rats using potassium bromate injection. The effect of NSFO and NSEO on indices of serum chemistry and hematology were studied. The results indicated that potassium bromate imparted drastic changes in serum chemistry and hematology e.g. it increased the blood cholesterol and blood glucose along with decreasing the insulin secretion. Oxidative stress also influenced the hematological attributes negatively but experimental diets were slightly successful in normalizing the values. The experimental diets especially essential oil that contains significant quantities of thymoquinone modulated the adverse consequences of oxidative stress with special reference to hematology and serological attributes. In the nutshell, NSFO and NSEO hold potential to mitigate the oxidative stress, and improved various serological and hematological attributes.
Highlights
Herbs and herbal products have gained immense recognition owing to their health promoting potential
Volatile fractions of N. sativa seeds are rich in antioxidants like thymoquinone, ρ-cymene, carvacrol, t-anethole, and 4-terpineol; possess varied antioxidant activity (Nickavar et al, 2003)
The purpose of the study was to exploit the rich phytochemistry of N. sativa oils against oxidative stress
Summary
Herbs and herbal products have gained immense recognition owing to their health promoting potential. Scientific innovation and technological advancement provided evidences to support the pivotal linkages between bioactive components and human health (Bjelakovic et al, 2014). Rich phytochemistry of plants is an important arena of research in the domain of nutrition and pharmacy. Nigella sativa (black seed) is quite common in the South Asia, Middle East, Sub-Saharan regions along with some parts of South-East Asia e.g. Malaysia and Indonesia. Its bioactive components reside in its fixed or essential oil e.g. healthy fatty acids, dihomolionolenic acid, tocopherols, phytosterols, and alkaloids like nigellicine, nigellidine & nigellimine (Cheikh-Rouhou et al, 2007). Volatile fractions (essential oil) of N. sativa seeds are rich in antioxidants like thymoquinone, ρ-cymene, carvacrol, t-anethole, and 4-terpineol; possess varied antioxidant activity (Nickavar et al, 2003)
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