NiGA MOF-based dispersive micro solid phase extraction coupled to temperature-assisted evaporation using low boiling point solvents for the extraction and preconcentration of butylated hydroxytoluene and some phthalate and adipate esters.

Abstract

The first-ever attempt to apply nickel gallic acid metal-organic framework (NiGA MOF) in analytical method development was done in this research by the extraction of some plasticizers from aqueous media. The greenness of the method is owing to the use of gallic acid and nickel as safe reagents and water as the safest solvent. Low boiling point solvents were applied as desorption solvents that underwent temperature-assisted evaporation in the preconcentration step. Performing the evaporation using a low-temperature water bath for a short period of time streamlines the preconcentration section. Into the solution of interest enriched with sodium sulfate, a mg amount of NiGA MOF was added alongside vortexing to extract the analytes. Following centrifugation and discarding the supernatant, a μL level of diethyl ether was added onto the analyte-loaded NiGA MOF particles and vortexed. The analyte-enriched diethyl ether phase was transferred into a conical bottom glass test tube and located in a water bath set at the temperature of 35 °C under a laboratory hood. After the evaporation, a μL level of 1,2-dibromoethane was added to the test tube and vortexed to dissolve the analytes from the inner perimeter of the tube. One microliter of the organic phase was injected into a gas chromatograph equipped with flame ionization detection. Appreciable extraction recoveries (61-98%), high enrichment factors (305-490), low limits of detection (0.80-1.74 μg L-1) and quantification (2.64-5.74 μg L-1), and wide linear ranges (5.74-1000 μg L-1) were obtained at the optimum conditions.