Abstract
(BJOG. 2019;126:729–735) Threatened preterm labor (PTL) (between 20 and 37 wks’ gestation) can be postponed using tocolytic therapy to transfer the patient to a center with a neonatal intensive care unit (NICU) and/or administer corticosteroids for the prevention or management of respiratory morbidity. Nifedipine is a calcium channel blocker that has been shown to be more effective and safer than ritodrine for tocolytic therapy of threatened PTL. This study aimed to compare a combination of nifedipine and sildenafil citrate (SC), a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase-5, compared with nifedipine alone, in terms of tocolytic effects in PTL cases.
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