Abstract
The synthesis of gem-1,3-enynes via Ni/Cu-catalyzed decarboxylative addition of alkynoic acids to terminal alkynes has been developed. It was found that the decarboxylation of an alkynoic acid led predominantly to gem-1,3-enynes instead of 1,3-diynes, which have been known to be formed through the coupling of terminal alkynes. A variety of gem-1,3-enynes were obtained in good yields. This catalytic system exhibited excellent regioselectivity and high functional group tolerance.
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