Nicotine metal complexes: synthesis, characterization and bioactivities of some main group and some transition metals

N S Awwad,H A Ibrahium,Y H Ju,A A Shati,A E Fazary,M Y Alfaifi

doi:10.4314/bcse.v34i3.7

Abstract

A number of some main group and transition metal nicotine complexes were synthesized and fully characterized using detailed structural and spectroscopic analysis techniques such as elemental analysis, molar conductivities, magnetic susceptibilities, IR, Raman and NMR techniques. Moreover, scanning electron micrographs and thermogravimetric analyses were also done. Cytotoxic activities of the binary nicotine metal complexes were tested and evaluated against HepG2 (human hepatocellular carcinoma), HPC3 (human prostate cancer), and HCT116 (human colorectal carcinoma) tumor cell lines. The antioxidant activities were examined by free radical scavenging assay. The antimicrobial activities of the synthesized complexes were evaluated against Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) microbes. The relationship between the chemical structure of the synthesized complexes and their biological influence as antimicrobial drugs was studied and evaluated.  KEY WORDS: Nicotine metal complexes, Cytotoxicity, Antioxidant, Antimicrobial  Bull. Chem. Soc. Ethiop. 2020, 34(3), 501-521. DOI: https://dx.doi.org/10.4314/bcse.v34i3.7

Highlights

Nicotine (3-((2S)-1-methylpyrrolidin-2-yl)pyridine, Scheme 1) is a bicyclic chiral alkaloid with a pyridine and a pyrrolidine cycles, possessing an asymmetric carbon and existing as two enantiomeric compounds (Scheme 1)
Vibration infrared spectral (IR) studies of all synthesized binary metal nicotine (NIC) complexes were recorded on a Shimadzu FT-IR 8000 spectrophotometer using KBr disc medium in the range 400–4000 cm−1 and the spectra were collected with a resolution of 2 cm−1 with 15 scans
The magnetic susceptibilities of the synthesized complexes at room temperature were found to be consistent with low spin distorted octahedral structures

Summary

Introduction

Nicotine (3-((2S)-1-methylpyrrolidin-2-yl)pyridine, Scheme 1) is a bicyclic chiral alkaloid with a pyridine and a pyrrolidine cycles, possessing an asymmetric carbon and existing as two enantiomeric compounds (Scheme 1). A number of binary nicotine complexes were synthesized and fully characterized using detailed structural and spectroscopic analysis techniques. The cytotoxic activities of the binary nicotine metal complexes were tested and evaluated against some tumor cell lines.

Results

Conclusion