Abstract
Abstract Prevalence of alkyl alkyl ketones in natural products, their use in biological probes, and their versatility as intermediates in organic synthesis, a wide variety of methods have been developed to access them. The most commonly used methods are the addition of a reactive organometallic reagent to an aldehyde followed by oxidation and the addition of pre‐formed organometallic nucleophiles to carboxylic acid derivatives. While both of these protocols are effective, the organometallic reagents can be limiting with complex, functionalized molecules. This article discusses nickel‐ catalyzed synthesis of ketones from alkyl halides and acid chlorides.
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